Angiogenesis in mouse

Monitoring of angiogenesis by 3D longitudinal in vivo imaging in mouse

In a mouse model of bone metastasis, proliferation of the vessels as well as osteolysis can be observed in vivo in the mouse hind limb.

(A) Left knee (control, no cancer): No angiogenesis at the tibial surface of the left knee and hardly any bone erosion. (B) Right knee (2 weeks after injection of cancer-inducing agent into the tibia): angiogenesis on the tibial surface as well as significant bone erosion clearly recognizable. (C) Right knee (5 weeks after injection of cancer-inducing agent): increased angiogenesis all over the right knee and strong deterioration of the bone.

For more details as well as the author and license information refer to:

Das NM, Hatsell S, Nannuru K, Huang L,Wen X, Wang L, et al. (2016) In Vivo Quantitative Microcomputed Tomographic Analysis of Vasculature and Organs in a Normal and Diseased  Mouse Model. PLoS ONE 11(2) doi.org/10.1371/journal.pone.0129912

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