FeraSpin™ Series

Nanoparticle MRI research toolbox

Order no:

FeraSpin™ XS MRI agent (1 x 5 injections): 130 - 095 - 140
FeraSpin™ XS MRI agent (5 x 5 injections): 130 - 095 - 141

FeraSpin™ S MRI agent (1 x 5 injections): 130 - 095 - 166
FeraSpin™ S MRI agent (5 x 5 injections): 130 - 095 - 167

FeraSpin™ M MRI agent (1 x 5 injections): 130 - 095 - 168
FeraSpin™ M MRI agent (5 x 5 injections): 130 - 095 - 169

FeraSpin™ L MRI agent (1 x 5 injections): 130 - 095 - 170
FeraSpin™ L MRI agent (5 x 5 injections): 130 - 095 - 171

FeraSpin™ XL MRI agent (1 x 5 injections): 130 - 095 - 172
FeraSpin™ XL MRI agent (5 x 5 injections): 130 - 095 - 173

FeraSpin™ XXL MRI agent (1 x 5 injections): 130 - 095 - 174
FeraSpin™ XXL MRI agent (5 x 5 injections): 130 - 095 - 175

price per item:
€2,650.00
Excluding VAT and shipping costs

The FeraSpin™ Series is a product family of six size-selected agents derived from FeraSpin R:
FeraSpin XS to FeraSpin XXL. The identical chemical composition and ultra-narrow size distribution of these fractions allow for fine-tuning of the pharmacologic profile according to your own innovative applications.

The unique series of size-selected superparamagnetic iron oxide (SPIO) nanoparticles:

  • Is analogous to human clinical agents
  • Encompasses particle fractions ranging from ultrasmall to large particle sizes
  • Offers tunable T1 and T2/T2* relaxation properties
  • The FeraSpin Series is Viscover's unique and powerful toolbox for nanoparticle MRI research

    • Apply the FeraSpin Series to

    • Adjust your unique MRI contrast agent for extended circulation, or macrophage and organ-specific uptake by the liver and spleen
    • Perform innovative in vitro and in vivo studies such as stem cell tracking, MR sequence development and Magnetic Particle Imaging (MPI)

    Characteristics of the FeraSpin Series with respect to particle size

    Blood half-life in rats of the different FeraSpin Series products in dependence of particle size

    FeraSpin™ Mean particle size
    (hydrodynamic diameter)    		 Relaxivity r2/r1
    (in water 37 °C, 1.41 T )
    XS 10 – 20 nm 3 - 5
    S 20 – 30 nm 5 - 9
    M 30 – 40 nm 9 - 22
    L 40 – 50 nm 22 - 32
    XL 50 – 60 nm 32 - 39
    XXL 60 – 70 nm 39 - 46

    FeraSpin™ Series tunable MRI Contrast
    FeraSpin XS, M, and XL (top to bottom) a pre contrast
    FeraSpin XS, M, and XL (top to bottom) accumulated in mouse liver Kupffer cells (30 min. post inject) leading to T2* hypointensity of healthy liver tissue. Accumulation and T2* effect clearly increase with particle size.
    Mouse whole-body T1-weighted MR angiography using FeraSpin XS.
    Left: FeraSpin XS, M, and XL (top to bottom) accumulated in mouse liver Kupffer cells leading to T2* hypointensity of healthy liver tissue (left column: pre-contrast, right column: 30 min. post inject) Accumulation and T2* effect clearly increase with particle size.
    Top right: Mouse whole-body T1-weighted MR angiography using FeraSpin XS.
    Selected references
    1. Waischkies, C. et al. (2017) SPIO-enhanced MRI as a nondestructive in vivo method to assess vascularization of 3D Degrapol® scaffolds planted on the Chorioallantoic membrane of the chick embryo in ovo. Matters Select, DOI: 10.19185/matters.201710000003.
    2. Jones, J. et al. (2015) Mesenchymal Stem Cells Improve Motor Functions and Decrease Neurodegeneration in Ataxic Mice. Mol. Ther. 23(1): 130–138
    3. Lohrke, J. et al. (2008) Characterization of superparamagnetic iron oxide nanoparticles by asymmetrical flow-field-flow-fractionation. Nanomedicine 3: 437-452.
    4. Ludwig, F. et al. (2012) Optimization of Magnetic Nanoparticles for Magnetic Particle Imaging. IEEE Transactions on Magnetics. 48(11): 3780-3783.
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